This week begins with a crucial battle in the NFC West. The Rams enter the game at 7-6, one game behind the Seattle Seahawks. The 49ers enter the game 6-7, coming off a big win over the Chicago Bears. The 49ers have dealt with their share of injuries and will again be short-handed on Thursday night.

For the Rams, Matthew Stafford is a QB2 option for me. In the backfield, Kyren Williams is getting the volume and making the most of it. He’s an RB1. In the passing game, Puka Nacua and Cooper Kupp are dominating. Both are WR1s for me, but there’s no other Rams’ pass catcher I’d take a shot on in a week with all 32 teams in action.

For the 49ers, Brock Purdy is keeping the team going. He’s a QB2 this week as well. George Kittle has been a beast and is a TE1. Among receivers, we could see Deebo Samuel more involved in the running game, which would help. Jauan Jennings is a low-end WR2 for me and Samuel is a low-end WR3. Both have upside. Isaac Guerendo is ailing but could play. Watch closely. If he misses, Patrick Taylor is a flex option. If he plays, I might stay away from both.

Now, on to the Week 15 picks.

NFL Picks, Week 15:

Rams Over 49ers
Chiefs Over Browns
Bengals Over Titans
Commanders Over Saints
Ravens Over Giants
Panthers Over Cowboys
Jaguars Over Jets
Texans Over Dolphins
Broncos Over Colts
Lions Over Bills
Eagles Over Steelers
Cardinals Over Patriots
Buccaneers Over Chargers
Packers Over Seahawks
Vikings Over Bears
Falcons Over Raiders

Last Week: 7-6
Season: 143-65

Matthew Fox is a graduate of the Radio, Television and Film program at Biola University, and a giant nerd. He spends his free time watching movies, TV, and obsessing about football. He is a member of the FSWA. You can find him @knighthawk7734 on Twitter and as co-host of the Fantasy Football Roundtable Podcast.