Week 4 of the NFL Season is under way. We have a packed Sunday slate, including our first London game of the season kicking things off early. We also have some great matchups. Below is my favorite games on the Sunday slate.

Early Games

New England Patriots (1-2) at Buffalo Bills (3-0)
About: The Patriots made the Super Bowl last season in part because they were able to take the AFC East from the Bills. But this season has been a struggle for Drake Maye and the whole offense. Now, they’re on the road against a Bills team that is humming along. This is a huge early matchup to determine the AFC East.

Jacksonville Jaguars (2-1) at Cincinnati Bengals (2-1)
About: The Jaguars have looked dominant in two home games but struggled on the road in Denver. The Bengals showed some great defensive improvement the first two weeks before slipping on Sunday in Pittsburgh. Which team will step up and break the trend in Week 4? This one has implications for the AFC.

Los Angeles Rams (1-2) at Philadelphia Eagles (2-1)
About: The Rams are off to a slow start, but Puka Nacua should be back this week. Meanwhile, the Eagles have been inconsistent and are coming off a terrible game in Chicago. Both teams are desperate for a win, but only one can get it. The Rams can ill-afford to drop to 1-3 if they want to make the Super Bowl.

Late Games:

Kansas City Chiefs (3-0) at Las Vegas Raiders (3-0)
About: This is a battle of unbeatens in the AFC West. The Chiefs are off to a strong start, but it’s the Raiders who are the surprise. The Raiders won only three games total in 2025, and already are off to a 3-0 start with Kirk Cousins. One of these teams will remain unbeaten at the end of the day and take the lead in the AFC West.

Denver Broncos (2-1) at San Francisco 49ers (3-0)
About: The 49ers are one of the NFL’s unbeatens, but it hasn’t been easy. The team is already beaten up and missing starters. The Broncos, meanwhile, struggled in Week 1 but managed home wins over the Jaguars and Rams. A win in San Francisco would set them on a great path as they try to get back to the playoffs.

Matthew Fox is a graduate of the Radio, Television and Film program at Biola University, and a giant nerd. He spends his free time watching movies, TV, and obsessing about football. He is a member of the FSWA. You can find him @knighthawk7734 on Twitter and as co-host of the Fantasy Football Roundtable Podcast.