We kick off Week 16 of the NFL Season with a massive matchup on Thursday Night. The 11-3 Los Angeles Rams are at the 11-3 Seattle Seahawks. Both teams are among the best in the NFC, but one will be a division winner and the other a Wild Card. So, this game has big ramifications.

The Rams got the win when these teams first met, giving them a leg up. A season sweep, along with pulling a game ahead, would like to ensure the Rams have the NFC West title and the best track for the No. 1 seed in the NFC. The Seahawks, meanwhile, could turn the tables with a win at home.

For the Rams, Davante Adams is injured and something of a long shot to play. If he does suit up, there’s no guarantee that he gets a full target load. I would make other plans. But I do like Matthew Stafford as a low-end QB1, and Kyren Williams as a low-end RB1. I also like Blake Corum as a flex option. In the passing game, Puka Nacua is a WR1. Meanwhile, I have liked the production from Colby Parkinson. He’s a consideration for me at TE.

For the Seahawks, they’ve been a good team that’s rough for fantasy. Sam Darnold is solid if unspectacular. He’s a mid-to-low QB2 option. In the backfield, Ken Walker and Zach Charbonnet have both been frustrating. Both are flex options, but neither is a lock for good production. Jaxon Smith-Njigba is a start. He’s a WR1 and the best Seahawks to play. The rest of the pass catchers are a toss-up, but I like Rashid Shaheed as a flex option.

Now, on to the Week 16 picks.

NFL Picks, Week 16:

Rams Over Seahawks
Eagles Over Commanders
Bears Over Packers
Bills Over Browns
Chargers Over Cowboys
Chiefs Over Titans
Saints Over Jets
Vikings Over Giants
Buccaneers Over Panthers
Dolphins Over Bengals
Broncos Over Jaguars
Falcons Over Cardinals
Lions Over Steelers
Texans Over Raiders
Ravens Over Patriots
49ers Over Colts

Last Week: 10-6
Season: 144-79

Matthew Fox is a graduate of the Radio, Television and Film program at Biola University, and a giant nerd. He spends his free time watching movies, TV, and obsessing about football. He is a member of the FSWA. You can find him @knighthawk7734 on Twitter and as co-host of the Fantasy Football Roundtable Podcast.