A crucial Week 16 in the NFL kicks off Thursday night with a battle between AFC West foes. The Denver Broncos and Los Angeles Chargers are also locked up in a battle for the Wild Card in the AFC, with the outcome of this game helping determine seeding. The Broncos have a one-game lead, but the Chargers beat them once earlier this year. Can Denver turn the tables?

For the Broncos, Bo Nix is a good start at quarterback. He had three turnovers in Week 15, but he also tossed three touchdowns. He’s a great Superflex option with Top 12 upside. I also like Courtland Sutton, the most consistent target for the Broncos’ offense. He’s a WR2 for me. It’s hard to tell what is going to happen game-to-game with the running game, so in the fantasy playoffs I’d tend to stay away from them all. But with Jaleel McLaughlin ruled out, that makes me more interested in Javonte Williams as a flex option. I also like Devaughn Vele as a low-end flex option.

For the Chargers, Justin Herbert is dealing with an ankle injury and a good Denver defense. He’s a QB2 for me. Ladd McConkey is having a great season, but he might see a lot of Patrick Surtain II. He’s a low-end WR2 for me. I’m staying away from the Chargers’ backs and tight ends. Will Dissly looks to be out, but Hayden Hurst may return. Stone Smartt is also there, but I don’t trust anyone from that group. I see Quentin Johnston as a low-end, boom/bust flex option.

Now, on to the Week 16 picks:

NFL Picks, Week 16:

Broncos Over Chargers
Texans Over Chiefs
Ravens Over Steelers
Bengals Over Browns
Falcons Over Giants
Lions Over Bears
Colts Over Titans
Rams Over Jets
Commanders Over Eagles
Cardinals Over Panthers
Vikings Over Seahawks
Bills Over Patriots
Jaguars Over Raiders
Dolphins Over 49ers
Buccaneers Over Cowboys
Packers Over Saints

Last Week: 13-3
Season: 156-68

Matthew Fox is a graduate of the Radio, Television and Film program at Biola University, and a giant nerd. He spends his free time watching movies, TV, and obsessing about football. He is a member of the FSWA. You can find him @knighthawk7734 on Twitter and as co-host of the Fantasy Football Roundtable Podcast.